After the defeat of Grand Master of the British Rite of the Templar Order Crawford Starrick in 1868, London enjoyed two decades of peace and stability. Sometime after Jacob Frye and his apprentice Jack's return from training with the Indian Assassins, the latter usurped control of the Rooks from his mentor in pursuit of his own idealized version of the Creed and extremist view of the Assassins' mission. The Whitechapel murders of 1888 were a direct result of Jacob opposing his renegade apprentice. In an attempt to bring an end to Jack's plans, Jacob sent Assassins pretending to be Mary Ann Nichols, Annie Chapman, Elizabeth Stride, Catherine Eddowes to stop his former student, all of which were brutally killed at the hands of Jack, who thereafter began to go by the pseudonym "Jack the Ripper". These murders marked the widespread moral decay of the Whitechapel district and the dispersion of terror throughout the city of London.
Media coverage of the Whitechapel murders would eventually increase, with Jack capitalizing on that fact by kidnapping the son of publisher Arthur Weaversbrook and coercing the latter into publishing his letters for him, to further spread his name and terror throughout London. Jacob picked up on Jack's intentions and confronted Weaversbrook on the night Catherine Eddowes and Elizabeth Stride were murdered, demanding that the publisher stop publicizing the Ripper's letters and turning him into a legend. Jack had anticipated this meeting and left a message for Jacob asking him, "How many more Assassins must die before you see the truth?" Jack then chased his former mentor to his lodgings, where the Master Assassin was overpowered, kidnapped, and locked up beneath Lambeth Asylum.
Before he was kidnapped, Jacob had requested the return of his sister, Evie Frye, to London from India. Evie, with the assistance of Inspector Frederick Abberline of the Metropolitan Police Service, eventually brought about the end of the Ripper murders and Jack's acts. She first killed Jack's right hand woman Olwyn Owers and then the chief warder of his personal prison at Deptford. In response, Jack eliminated any witnesses and evidence linking him to the Assassins at Debtford, his plans there having been foiled by the Frye twin. He then lured Evie to Lambeth Asylum for a family reunion with her brother, where he killed all staff members who potentially had memory of his childhood internment at the asylum.
Aware that she was being lured to Lambeth Asylum, Evie went to the madhouse and fought through a slew of inmates that had been released by Jack before her arrival. Beneath the asylum, she faced off with Jack and more inmates under his command, defeating them all in combat and bringing about the end of the Whitechapel murders with the death of the Assassin deserter. Following Jack's death, Abberline arrived to the site, with journalists not far behind. Evie informed him of Jack's Assassin allegiance and asked that he help her in keeping it a secret. As such, the journalists were called off and Jack's identity was forever rendered a mystery to the public.