- 主要词条: 《刺客信条II》故事情节
- 拉·沃尔佩的真实姓名为 Gilberto，虽然他仍希望埃齐奥叫他「拉·沃尔佩」。在游戏中，据透露「拉·沃尔佩」只是他的假名并没有提到真实姓名。
- 但丁·莫罗的前妻的名字从 Carlotta 改成 Gloria。
- 克里斯蒂娜·韦斯普奇的名字被改成 Cristina Calfucci。这最后在启示录中被修正。
- 安东尼奥的全名被赋予为 Antonio de Magianis。
- Different parts of the book detailed Ezio visiting Cristina's house several other times; such as after his father and brothers were executed to collect a pouch he left there, and before he met La Volpe, wherein he helped Cristina's fiancé.
- Ezio's relationship with Rosa was explored in more detail; whereas in the game they merely flirted with each other, in the novel it was confirmed that they were lovers.
- Claudia Auditore married Mario's guard captain.
- After the Battle of Forlì, Ezio became intimate with Caterina for a few months during his recovery.
- Ezio frequently changed his clothes to blend in better, such as wearing monks' robes when going to the monastery, or wearing poor civilian clothes within the village outside Forlì. In the game, Ezio's outfit generally stayed the same.
- Ezio's second Hidden Blade was a double-bladed weapon. This was reverted in the novel for Assassin's Creed: Revelations, as he wore one Hidden Blade on each hand.
- Ezio changed his Hidden Blade between the Poison Blade and the normal blade between missions. In-game, when Ezio got the Poison Blade, he could change it on the fly.
- The bullets for Ezio's Hidden Gun were provided by Leonardo, instead of the blacksmiths.
- The Hidden Blade was more often referred to as the "Codex blade", and even more often as the "spring-blade."
- Ezio often wielded his sword alongside either a dagger or one of his Hidden Blades. In the game, Ezio could only use one weapon at a time.
- Mario was shown many times to be nervous of the fact that Ezio shared the knowledge of the Codex with Leonardo, because he was not sure if anyone could be trusted with it.
- Ezio found many Codex pages on the dead remains of his enemies; such as retrieving one page from Vieri de' Pazzi's pouch and another from Emilio Barbarigo's satchel. In the game, Ezio found most of the Codex pages in Templar banks.
- Leonardo discovered that the Codex hid a map, even without having all of the pages. Ezio also noticed a map across the background in the novel. In the game, Ezio was the one to find it by using his Eagle Vision.
- During his battle with Ezio in San Gimignano, Vieri de' Pazzi fought at first with a battleaxe, drawing a sword and a dagger out later. In the game, he used only a sword.
- Ezio made the sign of the Cross over the corpses of certain targets as part of their last rites, such as Silvio Barbarigo and Dante Moro.
- Ezio walked out of the Vault to witness Rodrigo Borgia's death due to drinking poison, believing that he had failed his life's purpose of getting into the Vault. In the game, Ezio spared his life.
- This final scene took place in 1503, unlike in the game, where it took place in 1499.
- This scene was reverted in the following novel, wherein Ezio saw Rodrigo as he was leaving, but when he came back to check if Rodrigo was dead, he had gone, leaving only the Papal Cape behind.
- Ezio gave his father and brothers their final rites by placing them in a torched boat set adrift down the Arno, where in the game, Ezio just simply set their boat adrift.
- Maria and Claudia Auditore stayed in a convent near Monteriggioni after leaving Florence, where Claudia became a nun (although she later changed her mind and stayed at the Villa Auditore). In the game, they stayed in Mario's villa.
- Mention of a small incident of Ezio with Roberto, Vieri's drunk captain, was mentioned while in the game no such incident or character was present.
- Ezio rode a single horse and slew Borgia's men during his trip to Forlì with Leonardo da Vinci. In the game, he drove Leonardo's wagon. Additionally, Leonardo had a group of wagon riders and bodyguards with him before the attack, all of whom ran away at the first sign of trouble.
- When the other Assassins allowed Ezio to join their Order, they were all wearing the iconic Assassin hood; but in the game they were wearing their normal clothes.
- The events that covered the Battle of Forlì and the Bonfire of the Vanities were told in the novel. In the game, the two events were only accessible through downloadable content, unless on PC or the "game of the year", limited edition and "complete edition."
- The fight with Checco Orsi differed in the novel. In the game, Checco fled on foot; in the novel, he rode a wagon accompanied by guards until Ezio killed them and ended up fighting Checco. Also, Checco did not stab Ezio in the side, but slashed Ezio's arm.
- Girolamo Savonarola was said to have been executed along with two others, Domenico and Silvestro.
- Ezio did not throw the knife that disarmed Savonarola, instead it was Niccolò Machiavelli. In the game, Niccolò would only throw the knife if the player did not press the button prompt during the cutscene.
- To end Savonarola's suffering, Ezio shot him with the Hidden Gun. In the game, he lunged forward and stabbed Savonarola with his Hidden Blade.
- Some citizens left Florence during the Bonfire of the Vanities. In the game, they were still seen walking around afterwards.
- While Ezio was speaking to Minerva in the Vault, there was no mention of Desmond or the modern-day Assassins. However, Minerva still said that Ezio only anchored the one for whom the message was intended, hence the message was still not meant for Ezio.
- Most of the dialogues were changed while in The Secret Crusade novel of Altaïr's story, scarcely any dialogues were altered.
- 主要词条: 刺客信条：文艺复兴/术语
该小说在英国于《刺客信条II》发布后六天的2009年11月26日，北美于2010年2月23日发布。2009年11月26日发布的点燃版本可以在 Amazon.com 购买。