In 1480, Leonardo da Vinci was offered a commission in Venice, and thus took a carriage into the Apennine Mountains during his journey from Florence to the port in Romagna. After assassinating Jacopo de' Pazzi, the Assassin Ezio Auditore da Firenze followed the artist into the range.
There, Ezio found Leonardo alongside his broken cart, where he was attempting to fix the shattered wheel. The Assassin helped him repair the carriage, and caught his first glimpse of Leonardo's Flying Machine, which was loaded into the back of the cart.
Together they set off for Forlì, from where they would take a boat to Venice. However, Borgia guards on horseback pursued them through the range, setting fires in front of them, and attempting to board the carriage itself.
The two managed to evade their attempts, and upon reaching the mountain range's end, Ezio told Leonardo to go ahead in the carriage, while he stayed to take care of the guards.
- 亚平宁山脉是刺客信条II中唯一完全没有商店和恶名值的地区， and to feature a piece from the Assassin's Creed soundtrack, entitled "Dunes of Death."